Pulsed Field Ablation

Request Clinical Evidence for the Centauri™ PFA System

A curated collection of clinical studies, investigator experiences, and scientific evidence supporting focal PFA with Centauri™.

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The next chapter of AF ablation has already begun.

Pulsed Field Ablation is rapidly changing the treatment of atrial fibrillation.
As the field evolves, physicians face an important question:   

How do you adopt what's next without disrupting what already works?

Innovation should fit your workflow.
Not the other way around.

At BIOTRONIK, we believe PFA adoption should feel like progress, not disruption. 
Because meaningful innovation isn't about replacing what works. It's about adding what's next.
 

Designed around the way you already work.

Changing technology shouldn't mean changing everything else. Centauri was developed to bring Pulsed Field Ablation into today's EP lab, not replace it.

Centauri PFA System
Pulsed Field Ablation
Keep your workflow.

Flexible

Centauri integrates with commercially available contact-force catheters and leading mapping systems, allowing physicians to adopt focal PFA without changing established procedural workflows.
Safe
Keep your confidence.

Safe

The proprietary Wave1™ waveform was developed for controlled, selective tissue ablation while minimising microbubbles and muscle stimulation. Designed to support procedural confidence from the very first case.
Proven
Keep clinical confidence.

Proven

With more than 10,000 patients treated worldwide and a growing body of clinical evidence, Centauri combines established experience with durable clinical outcomes.
Efficient
Add what's next.

Efficient

Adopting PFA shouldn't require rebuilding your EP lab.Centauri provides a practical pathway into Pulsed Field Ablation using familiar workflows and existing infrastructure.

A practical path into PFA.

Switching to Pulsed Field Ablation shouldn't require rebuilding your EP lab.

Centauri integrates into established workflows, works with commercially available contact-force catheters and leading mapping systems, and is designed for straightforward implementation.

  • no major workflow changes
  • no dedicated lab redesign
  • use of certified catheters already available in the lab
  • plug-and-play integration
  • straightforward generator installation
  • only the Wave1™ Kit required for procedures

 

From the EP Lab

Adopting PFA shouldn't require rebuilding your EP lab.

"Focal ablation is the cornerstone of my practice for complex cases. Our team has shifted AF ablations from radiofrequency to exclusively PFA due to Centauri's ability to integrate with market-leading mapping systems and contact force sensing catheters, enabling both precision and durability for the lesion set."

Dr. Ante Anić, MD University Hospital Centre Split, Split (Croatia)

 

Clinical confidence starts with clinical evidence.

Clinical innovation only matters when it delivers meaningful outcomes.

Centauri is supported by growing clinical evidence demonstrating durable lesion formation, 
encouraging long-term freedom from atrial fibrillation and compatibility with established EP workflows.
10,000+

10,000+

Patients treated worldwide with established clinical experience
90.2%

90.2%

Freedom from clinically significant atrial arrhythmia at 12 months¹
89%

89%

Pulmonary vein isolation durability at 90-day remapping²
Compatible

Compatible

with leading mapping systems and commercially available contact-force catheters

Footnotes

¹ Anić A, Phlips T, Brešković T, Mediratta V, Girouard S, Jurišić Z, Sikirić I, Lisica L, Koopman P, Antole N, Vijgen J. Pulsed Field Ablation Using Focal Contact Force–Sensing Catheters for Treatment of Atrial Fibrillation: 1-Year Outcomes of the ECLIPSE AF Study. Circulation: Arrhythmia and Electrophysiology. 2025;18:e012794.

² Anić A, et al. Pulsed Field Ablation Using Focal Contact Force-Sensing Catheters for Treatment of Atrial Fibrillation: Acute and 90-Day Invasive Remapping Results. Europace. 2023;25(6):euad147.